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We actuate with light & magnets, we fold & unfold DNA, we cell-free express proteins, we play with drops, marbles & interfaces, we organize particles, we harness coffee rings.

Our paper "Reversible supra-folding of user-programmed functional DNA nanostructures on fuzzy cationic substrates" has just been accepted in Angewandte Chemie.


It was also selected as a so-called "hot paper".


Abstract: We report that user-defined DNA nanostructures, such as two-dimensional (2D) origamis and nanogrids, undergo a rapid higher-order folding transition, referred to as supra-folding, into three-dimensional (3D) compact structures (origamis) or well-defined μm-long ribbons (nanogrids), when they adsorb on a soft cationic substrate prepared by layer-by-layer deposition of polyelectrolytes. Once supra-folded, origamis can be switched back on the surface into their 2D original shape through addition of heparin, a highly charged anionic polyelectrolyte known as an efficient competitor of DNA-polyelectrolyte complexation. Orthogonal to DNA base-pairing principles, this reversible structural reconfiguration is also versatile; we show in particular that i) it is compatible with various origami shapes, ii) it perfectly preserves fine structural details as well as sitespecific functionality, and iii) it can be applied to dynamically address the spatial distribution of origami-tethered proteins.

Reference:
Reversible supra-folding of user-programmed functional DNA nanostructures on fuzzy cationic substrates
K. Nakazawa, F. El Fakih, V. Jallet, C. Rossi–Gendron, M. Mariconti, L. Chocron, M. Hishida, K. Saito, M. Morel, S. Rudiuk,* D. Baigl*
Angew. Chem. Int. Ed. 2021,doi: 10.1002/anie.202101909
   -doi : 10.1002/anie.202101909