We actuate with light & magnets, we fold & unfold DNA, we cell-free express proteins, we play with drops, marbles & interfaces, we organize particles, we harness coffee rings.

Sergii Rudiuk, CR CNRS


Sergii is an expert in DNA, RNA, surfactants, and nanoparticles. Fan of hard rock music, Sergii can speak about 5 languages.

Birthdate: 09 November 1982
Adress : 24, rue Lhomond, 75005 Paris, France
Email :

Current positions

  • Since 2013: CNRS Researcher (CRCN), UMR 8640, Department of Chemistry, Ecole Normale Supérieure (ENS), Paris
  • Since 2020: Associate Professor PSL/ENS (additional position)

Research interests

    - DNA nanotechnology
    - DNA-protein conjugates
    - Atomic Force Microscopy (AFM)
    - Physical chemistry of biological macromolecules
    - Interfacial phenomena

Research experience

  • 2011 - 2013:   postdoctoral position in the Department of Chemistry, Ecole Normale Supérieure (ENS), in the team of Pr. Damien Baigl
                            - DNA-protein conjugates for bio- and nano- technology

  • 2010 - 2011:   postdoctoral position in the Department of Chemistry, Ecole Normale Supérieure (ENS), in the team of Dr. Christophe Tribet
                            - Interfacial aggregation of therapeutic antibodies

  • 2009 - 2010:   postdoctoral position in Yoshikawa laboratory, Kyoto University, Japan
                            - Enhancement of surfactants-induced DNA compaction by negatively charged nanoparticles
                            - Selective photocontrol of genes expression

  • 2005 - 2009:   PhD research in IMRCP laboratory, Paul Sabatier University, Toulouse, France
                            - Influence of DNA compaction on the photostability
                            - DNA protection by antioxydant vesicles


  • 2021:        HDR thesis defended in Ecole Normale Supérieure (ENS)
                     Title: “Weak interactions, strong effects: from photocontrol of DNA to preparation of DNA-based nanomaterials”

  • 2009:        PhD thesis, IMRCP laboratory, Paul Sabatier University, Toulouse, France (supervision of Dr. Isabelle Rico-Lattes )
                     Title: “Influence of DNA complexation with cationic surfactants, polymers and lipids on its photooxidative damage”

  • 2005:        Master 2 degree with honours, Taras Shevchenko National University, Kiev, Ukraine (supervision of Dr. Zoia Voitenko)
                     Major : “Organic Chemistry” and “Macromolecular Chemistry”

Publication list

40. Mariconti, M., L. Dechamboux, M. Heckmann, J. Gros, M. Morel, V. Escriou, D. Baigl, C. Hoffmann*, S. Rudiuk*
      Intracellular delivery of functional proteins with DNA-protein nanogels-lipids complex
      J. Am. Chem. Soc. 2024, accepted.

39. Rossi-Gendron, C., F. El Fakih, L. Bourdon, K. Nakazawa, J. Finkel, N. Triomphe, L. Chocron, M. Endo, H. Sugiyama, G. Bellot, M. Morel, S. Rudiuk, D. Baigl
     Isothermal self-assembly of multicomponent and evolutive DNA nanostructures
     Nature Nanotechnology 2023, 18, 1311–1318.

38. Vialetto, J., T. Gaichies, S. Rudiuk, M. Morel, D. Baigl
     Versatile deposition of complex colloidal assemblies from the evaporation of hanging drops
      Adv. Sci. 2023, 2307893.
37. Jacková, B., G. Mottet, S. Rudiuk, M. Morel, D. Baigl
     DNA-encoded immunoassay in picoliter drops: a minimal cell-free approach
      Adv. Biology 2023, 2200266.

36. Vialetto, J., S. Rudiuk, M. Morel, D. Baigl
      Photothermally reconfigurable colloidal crystals at a fluid interface, a generic approach for optically tunable lattice properties 
      J. Am. Chem. Soc. 2021, 143, 30, 11535–11543.

35. Mariconti, M., M. Morel, D. Baigl, S. Rudiuk*
      Enzymatically active DNA-protein nanogels with tunable cross-linking density 
      Biomacromolecules 2021, 22 (8), 3431 - 3439.

34. Nakazawa, K., F. El Fakih, V. Jallet, C. Rossi–Gendron, M. Mariconti, L. Chocron, M. Hishida, K. Saito, M. Morel, S. Rudiuk,* D. Baigl*
      Reversible supra-folding of user-programmed functional DNA nanostructures on fuzzy cationic substrates 
      Angew. Chem. Int. Ed. 2021, 60, 15214 –15219.

33. Poulichet, V., M. Morel, S. Rudiuk, D. Baigl
      Liquid-liquid coffee-ring effect
      J. Colloid Interface Sci. 2020, 573, 370-375.

32. Galy, P., S. Rudiuk, M. Morel, D. Baigl
      Self-Propelled Water Drops on Bare Glass Substrates in Air: Fast, Controllable, and Easy Transport Powered by Surfactants
      Langmuir 2020, 36, 25, 6916–6923.

31. Vialetto, J., S. Rudiuk, M. Morel, D. Baigl
      From-bulk crystallization of inorganic nanoparticles at the air/water interface: tunable organization and intense structural colors
      Nanoscale 2020, 12, 6279-6284.

30. Law-Hine, D., S. Rudiuk, A. Bonestebe, R. Ienco, S. Huille, C. Tribet
      Distinctive Low-Resolution Structural Features of Dimers of Antibody Drug Conjugates and Parent Antibody determined by Small-Angle X-Ray Scattering
      Mol. Pharmaceutics 2019, 16(12), 4902–4912.

29. Zhou, L., P. Retailleau, M. Morel, S. Rudiuk, D. Baigl
      Photoswitchable fluorescent crystals obtained by the photoreversible co-assembly of a nucleobase and an azobenzene intercalator
      J. Am. Chem. Soc. 2019, 141, 9321-9329.

28. Vialetto, J., M. Anyfantakis, S. Rudiuk, M. Morel, D. Baigl
      Photoswitchable Dissipative Two-Dimensional Colloidal Crystals
      Angew. Chem. Int. Ed. 2019, 58(27), 9145-9149.

27. Hayakawa, M., J. Vialetto, M. Anyfantakis, M. Takinoue, S. Rudiuk, M. Morel, D. Baigl
      Effect of Moderate Magnetic Fields on the Surface Tension of Aqueous Liquids: a Reliable Assessment
      RSC Adv. 2019, 9, 10030–10033.

26. Evenou, P., J. Rossignol, G. Pembouong, A. Gothland, D. Colesnic, R. Barbeyron, S. Rudiuk, A.-G. Marcelin, M. Ménand, D. Baigl, V. Calvez,
      L. Bouteiller, M. Sollogoub
      Bridging β‐Cyclodextrin Prevents Self‐Inclusion, Promotes Supramolecular Polymerization, and Promotes Cooperative Interaction with Nucleic Acids
      Angew. Chem. Int. Ed. 2018, 57, 7753-7758.

25. Vialetto, J., M. Hayakawa, N. Kavokine, M. Takinoue, S. N. Varanakkottu, S. Rudiuk, M. Anyfantakis, M. Morel, D. Baigl
      Magnetic actuation of discrete liquid entities with a deformable paramagnetic liquid substrate
      Angew. Chem. Int. Ed. 2017, 56, 16565-16570.

24. Anyfantakis, M., S. N. Varanakkottu, S. Rudiuk, M. Morel, D. Baigl
      Evaporative Optical Marangoni Assembly (eOMA): tailoring the three-dimensional morphology of individual deposits of nanoparticles from sessile drops
      ACS Appl. Mater. Interfaces 2017, 9 (42), 37435–37445.

23. Zhou, L., M. Morel, S. Rudiuk, D. Baigl
      Intramolecularly Protein-Crosslinked DNA Gels: new biohybrid nanomaterials with controllable size and catalytic activity
      Small 2017, 13(28), 1700706.

22. Devineau, S., M. Anyfantakis, L. Marichal, L. Kiger, M. Morel, S. Rudiuk, D. Baigl
      Protein adsorption and reorganization on nanoparticles probed by the coffee-ring effect: application to single point mutation detection
      J. Am. Chem. Soc. 2016, 138, 11623−11632.

21. Kavokine, N., M. Anyfantakis, M. Morel, S. Rudiuk, T. Bickel, D. Baigl
      Optical transport of liquid marbles in and against surface flows
      Angew. Chem. Int. Ed. 2016, 55, 11183 –11187.

20. Lee Tin Wah, J., C. David, S. Rudiuk, D. Baigl, A. Estevez-Torres
      Observing and controlling the folding pathway of DNA origami at the nanoscale
      ACS Nano 2016, 10(2), 1978–1987.

19. Bergen, A., S. Rudiuk, M. Morel, T. Le Saux, H. Ihmels, D. Baigl
      Photodependent melting of unmodified DNA using a photosensitive intercalator: a new and generic tool for photoreversible assembly of
      DNA nanostructures at constant temperature

      Nano Lett. 2016, 16 (1), 773–780.

18. Varanakkottu, S. N., M. Anyfantakis, M. Morel, S. Rudiuk, D. Baigl
      Light-directed particle patterning by evaporative optical Marangoni assembly
      Nano Lett. 2016, 16 (1), 644–650.

17. Nurdin, L., A. Venancio-Marques, S. Rudiuk, M. Morel, D. Baigl
      High-throughput photocontrol of water drop generation, fusion, and mixing in a dual flow-focusing microfluidic device
      C. R. Chimie 2016, accepted, DOI : 10.1016/j.crci.2015.07.012.

16. Anyfantakis, M., Z. Geng, M. Morel, S. Rudiuk, D. Baigl
      Modulation of the coffee-ring effect in particle/surfactant mixtures: the importance of particle-interface interactions
      Langmuir 2015, 31, 4113−4120.

15. Venancio-Marques A., A. Bergen, C. Rossi-Gendron, Rudiuk S., D. Baigl
      Photosensitive polyamines for high-performance photocontrol of DNA higher-order structure
      ACS Nano 2014, 8, 3654–3663.

14. Mani, K. N., Rudiuk S., D. Baigl
      Spatially controlled DNA unzipping by microfluidic interface positioning on a molecule perpendicular to a multicomponent flow
      Chem. Commun. 2013, 49 (61), 6858 – 6860.

13. Rudiuk S., A. Venancio-Marques, G. Hallais, D. Baigl
      Preparation of one- to four-branch silver nanostructures of various sizes by metallization of hybrid DNA-protein assemblies
      Soft Matter 2013, 9, 9146-9152.

12. Rudiuk S., A. Venancio-Marques, D. Baigl
      Enhancement and modulation of enzymatic activity through higher-order structural changes of giant DNA-protein multibranch conjugates
      Angew. Chem. Int. Ed. 2012, 51, 12694 –12698.

11. Diguet A., M. Yanagisawa, Y.-J. Liu, E. Brun, S. Abadie, S. Rudiuk, D. Baigl
      UV-Induced Bursting of Cell-Sized Multi-Component Lipid Vesicles in a Photosensitive Surfactant Solution
      J. Am. Chem. Soc. 2012, 134, 4898−4904.

10. Rudiuk S., L. Cohen-Tannoudji, S. Huille, C. Tribet
      Importance of the dynamics of adsorption and of a transient interfacial stress on the formation of aggregates of IgG antibodies
      Soft Matter 2012, 8, 2651-2661.

9.   Schiessel H., M. D. Correa-Rodríguez, S. Rudiuk, D. Baigl, K. Yoshikawa
      Theory of DNA-cationic micelle complexation
      Soft Matter 2012, 8, 9406-9411.

8.   Liu Y.-J., A. Pallier, J. Sun, S. Rudiuk, D. Baigl, M. Piel, E. Marie, C. Tribet
      Non-monotonous variation of the LCST of light-responsive, amphiphilic poly(NIPAM) derivatives
      Soft Matter 2012, 8, 8446-8455.

7.   Rudiuk S., K. Yoshikawa, D. Baigl
      Enhancement of DNA Compaction by Negatively Charged Nanoparticles. Effect of Nanoparticle Size and Surfactant Chain Length
      J. Colloid Interface Sci, 2012, 368, 372-377.

6.   Rudiuk S., T. Hara, H. Saito, K. Yoshikawa, D. Baigl
      Light-Regulated mRNA Condensation by a Photosensitive Surfactant Works as a Series Photoswitch of Translation Activity in the Presence of Small RNAs
      Biomacromolecules 2011, 12, 3945−3951.

5.   Rudiuk S., K. Yoshikawa, D. Baigl
      Enhancement of DNA Compaction by Negatively Charged Nanoparticles. Application to Reversible Photocontrol of DNA Higher-Order Structure
      Soft Matter 2011, 7, 5854-5860.

4.   Rudiuk S., S. Franceschi-Messant, N. Chouini-Lalanne, E. Perez, I. Rico-Lattes
      DNA photooxidative damage hazard in transfection complexes
      Photochem. Photobiol. 2011, 87, 103-108.

3.   Rudiuk S., M. Delample, S. Franceschi-Messant, N. Chouini-Lalanne, E. Perez, J.-C. Garrigues, I. Rico-Lattes
      Spontaneous vesicle formation by caffeate ion-pair surfactants: antioxidant properties and application to DNA protection
      J. Disp. Sci. Tech. 2010, 31, 384–391.

2.   Rudiuk S., S. Franceschi-Messant, N. Chouini-Lalanne, E. Perez, I. Rico-Lattes
      Modulation of photo-oxidative DNA damage by cationic surfactant complexation
      Langmuir 2008, 24, 8452-8457.

1.   Rudiuk S.A.; Voitenko, Z.V.; Riabov, S.V.; Roshal, A.D.
      Molecular complexes of 4,10-dihydrothieno[3',2':5,6]pyrimido[2,1-a]isoindol-4-ones with β-cyclodextrin
      J. Incl. Phenom. Macrocycl. Chem. 2007, 57(1-4), 415-417.

Encyclopedia and book chapters

-   A. Venancio-Marques, S. Rudiuk, D. Baigl
    Structures hybrides ADN-protéines : synthèse et applications
    Techniques de l'ingénieur 2014, in 172


-   Nakazawa, K., A. Lévrier, S. Rudiuk, A. Yamada, M. Morel, D. Baigl
    Budding-driven localization of lipid domains at prescribed positions in confined giant unilamellar vesicles
    ChemRxiv 2023 (preprint), doi: 10.26434/chemrxiv-2023-c0v23

-   Abodja, O., N. Touati, M. Morel, S. Rudiuk, D. Baigl
    ATP/azobenzene-guanidinium self-assembly into fluorescent and multi-stimuli responsive supramolecular aggregates
    ChemRxiv 2023 (preprint), doi: 10.26434/chemrxiv-2023-qt9xd